Heart failure impairs cerebral oxygenation during exercise in patients with COPD.
نویسندگان
چکیده
Summarizing sentence Exercise capacity and cerebral oxygenation are reduced in COPD-heart failure overlap compared to COPD in isolation.
منابع مشابه
Effects of heart failure on cerebral blood flow in COPD: Rest and exercise
Cerebral blood flow (CBF) and oxygenation (COx) are generally well-preserved in COPD. It is unknown whether prevalent cardiovascular co-morbidities, such as heart failure, may impair CBF and COx responses to exertion. Eighteen males with moderate-to-severe COPD (8 with and 10 without overlapping heart failure) underwent a progressive exercise test with pre-frontal CBF and COx measurements (indo...
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Background: It was hypothesized that the use of Pentoxifylline would increase arterial O2 saturation and increase exercise tolerance in patients with Chronic Obstructive Pulmonary Disease (COPD). Methods: We tested this hypothesis in 23 patients with COPD and pulmonary hypertension. Patients were randomized to receive Pentoxifylline or placebo, each for a 12-week period, in a prospectiv...
متن کاملHeart failure impairs cerebral oxygenation during exercise in patients with COPD
provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline. Respir Res 2005; 6: 144. 4 Beydon N, Davis SD, Lombardi E, et al. An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 2007; 175: 1304–1345. 5 Hall GL, Gangell C, Fukushima T, et al. Applic...
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Impairment in oxygen (O2) delivery to the central nervous system ("brain") and skeletal locomotor muscle during exercise has been associated with central and peripheral neuromuscular fatigue in healthy humans. From a clinical perspective, impaired tissue O2 transport is a key pathophysiological mechanism shared by cardiopulmonary diseases, such as chronic obstructive pulmonary disease (COPD) an...
متن کاملCompromised Cerebrovascular Regulation and Cerebral Oxygenation in Pulmonary Arterial Hypertension
BACKGROUND Functional cerebrovascular regulatory mechanisms are important for maintaining constant cerebral blood flow and oxygen supply in heathy individuals and are altered in heart failure. We aim to examine whether pulmonary arterial hypertension (PAH) is associated with abnormal cerebrovascular regulation and lower cerebral oxygenation and their physiological and clinical consequences. M...
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عنوان ژورنال:
- The European respiratory journal
دوره 42 5 شماره
صفحات -
تاریخ انتشار 2013